Don't miss the upcoming 2025 ISLH January Webinar! Register now!
07/01/2025
On Thursday, January 23, 2024 the International Society for Laboratory Hematology will host the first webinar in the 2025 e-Learning series: "Multicenter Evaluation of Light Transmission Platelet Aggregation Reagents: Communication from the ISTH SSC Subcommittee on Platelet Physiology".
The webinar will be held by Marie Christine Alessi, MD, PhD, Lab Hematology, CHU Timone & Aix Marseille University, Marseille, France.
Overview
Light transmission aggregation (LTA) is commonly utilized in clinical and research settings, but there is a lack of consistency across laboratories.
The variability in agonist sourcing has not been thoroughly evaluated. The presented international study involving 28 laboratories aims to determine if different platelet agonist sources contribute to inconsistencies in LTA results. Additionally, it seeks to assess interindividual variability in LTA responses to aid in the interpretation of normal and pathological results.
The results suggest that implementing standardization principles could reduce variability from different activator sources.
The high interindividual variability observed in responses indicates a need for careful interpretation of results before labeling them as abnormal, although it appears that differences due to agonist sources do not worsen platelet dysfunction in patients on antiplatelet therapies.
Learning Objectives:
- For most of the agonists high, intermediate and low responders to the activator are evidenced.
- An essential aspect of light transmission platelet aggregation involves the establishment of normal reference ranges for each testing condition.
- As the normal response to low activator concentrations exhibits a broad distribution, it is suggested to use a high number of healthy controls to establish cutoff limits.
- The introduction of reference reagents (standards) to harmonize the biological activity (potency) of different activator sources may be useful.
All webinars will begin promptly at 11:00 AM Eastern Time US (17:00 CET) and are approximately 50 minutes long. There is no charge to participate in the live webinar.
We look forward to your participation in this event!
