Don't miss the upcoming 2025 ISLH February Webinar! Register now!
10/02/2025
On Thursday, February 20th, at 11:00 AM ET (17:00 PM CET) 2024 the International Society for Laboratory Hematology will host the 2nd webinar in the 2025 e-Learning series: "Laboratory Investigation of Contact Factor Deficiencies"".
The webinar will be held by Thomas Renné, MD, PhD Professor of Clinical Chemistry, University Medical Center Hamburg (UKE), Hamburg, Germany
Cara Lunn Shirai, PhD, HCLD(ABB) will be the Moderator.
Overview
Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. This system starts a cascade of procoagulant and proinflammatory reactions via the intrinsic pathway of coagulation, and the bradykinin-producing kallikrein-kinin system, respectively. The biochemistry of the contact system in vitro is well understood; however its in vivo functions are just beginning to emerge.
Our laboratory has originally shown that FXII is essential for thrombus formation while being dispensable for hemostatic processes that terminate blood loss. Challenging the dogma of a coagulation balance, targeting factor XII protected from thromboembolic disease without interfering with hemostasis. In contrast, excess FXII activity is associated with a life-threatening inflammatory disorder, Hereditary angioedema. Platelet polyphosphate (an inorganic polymer) and mast cell heparin function as in vivo FXII activators with implications on the initiation of thrombosis and edema.
The key aspect of this presentation will be an overview on the contact system and its activator polyphosphate and its role in coagulation assays.
Learning Objectives:
- Recognize the aPTT assay as a measure for contact factor deficiency states
- Gain knowledge about inorganic polymer polyphosphate
- Gain knowledge about the role of the polyP-FXII-FXI pathway in thrombosis sparing hemostasis
We look forward to your participation in this event!
Notizie collegate
